CYP3A4: Difference between revisions
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== | == Drug Metabolism == | ||
CYP3A4 is thought to affect the metabolism of 30-60% of the drugs on the market [https://www.pharmgkb.org/gene/PA130?tabType=tabVip#tabview=tab3&subtab=32] [http://www.pharmacytimes.com/publications/issue/2008/2008-09/2008-09-8687]. An orally prescribed drug can take a while to arrive at its target cell and along the way the body has enzymes that filter out the drug dampening its efficacy. In | CYP3A4 is thought to affect the metabolism of 30-60% of the drugs on the market [https://www.pharmgkb.org/gene/PA130?tabType=tabVip#tabview=tab3&subtab=32] [http://www.pharmacytimes.com/publications/issue/2008/2008-09/2008-09-8687]. An orally prescribed drug can take a while to arrive at its target cell and along the way the body has enzymes that filter out the drug dampening its efficacy. Of those enzymes, CYP3A4 is a main player and still a lot more needs to be learned. In many cases, like that of the ß2 receptor, there is only a fraction of the drug remaining after what is known as the first-pass metabolism so that by the time the drug gets to the circulatory system where it can be delivered to the tissues its potency has already been compromised <ref name="h"> PMCID: PMC2045626</ref>. | ||
One way to work around this is by intravenous administration so as to bypass the biological filters of the gut and go right into the bloodstream. | One way to work around this is by intravenous administration so as to bypass the biological filters of the gut and go right into the bloodstream. | ||
[[Image:First-pass metabolism.jpg]] | [[Image:First-pass metabolism.jpg]] | ||
