4xxw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4xxw is ~~ON HOLD until Mar 31 2017~~

==Crystal structure of mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1-2 splice variant==

~~Authors~~: ~~Narui~~, Y., ~~Sotomayor~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[4xxw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XXW FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xxw OCA], [http://pdbe.org/4xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xxw RCSB], [http://www.ebi.ac.uk/pdbsum/4xxw PDBsum]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. [[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.

== Function ==

[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. [[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Narui, Y]]

[[Category: Sotomayor, M]]

[[Category: ~~Narui, Y~~]]

[[Category: Calcium binding protein]]

[[Category: Cell adhesion]]

[[Category: Hearing]]

[[Category: Mechanotransduction]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4xxw is ON HOLD  until Mar 31 2017
+==Crystal structure of mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1-2 splice variant==
+<StructureSection load='4xxw' size='340' side='right' caption='[[4xxw]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
-Authors: Narui, Y., Sotomayor, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4xxw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XXW FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xxw OCA], [http://pdbe.org/4xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xxw RCSB], [http://www.ebi.ac.uk/pdbsum/4xxw PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. [[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.
+== Function ==
+[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. [[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Narui, Y]]
 [[Category: Sotomayor, M]]
-[[Category: Narui, Y]]
+[[Category: Calcium binding protein]]
+[[Category: Cell adhesion]]
+[[Category: Hearing]]
+[[Category: Mechanotransduction]]