5hyj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5hyj is ~~ON HOLD until Paper Publication~~

==1E6 TCR in Complex with HLA-A02 carrying AQWGPDPAAA==

~~Authors~~: ~~Rizkallah~~, P.J., ~~Bulek~~, A.M., ~~Cole~~, D.K.~~, Sewell, A~~.K.

== Structural highlights ==

<table><tr><td colspan='2'>[[5hyj]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYJ FirstGlance]. <br>

~~Description~~:

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyj OCA], [http://pdbe.org/5hyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyj RCSB], [http://www.ebi.ac.uk/pdbsum/5hyj PDBsum]</span></td></tr>

[[Category: Bulek, A.M]]

</table>

[[Category: Cole, D.K]]

== Disease ==

[[Category: Sewell, A.K]]

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>

[[Category: ~~Rizkallah, P.J~~]]

== Function ==

[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

== References ==

__TOC__

</StructureSection>

[[Category: Bulek, A M]]

[[Category: Cole, D K]]

[[Category: Rizkallah, P J]]

[[Category: Sewell, A K]]

[[Category: 1e6-tcr]]

[[Category: Cross-reactivity]]

[[Category: Hla-a02]]

[[Category: Immune system]]

[[Category: Immuno]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5hyj is ON HOLD  until Paper Publication
+==1E6 TCR in Complex with HLA-A02 carrying AQWGPDPAAA==
+<StructureSection load='5hyj' size='340' side='right' caption='[[5hyj]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
-Authors: Rizkallah, P.J., Bulek, A.M., Cole, D.K., Sewell, A.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5hyj]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYJ FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c07|5c07]], [[5c08|5c08]], [[5c09|5c09]], [[5c0a|5c0a]], [[5c0b|5c0b]], [[5c0c|5c0c]], [[5c0d|5c0d]], [[5c0e|5c0e]], [[5c0f|5c0f]], [[5c0g|5c0g]], [[5c0h|5c0h]], [[5c0i|5c0i]], [[5c0j|5c0j]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyj OCA], [http://pdbe.org/5hyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyj RCSB], [http://www.ebi.ac.uk/pdbsum/5hyj PDBsum]</span></td></tr>
-[[Category: Bulek, A.M]]
+</table>
-[[Category: Cole, D.K]]
+== Disease ==
-[[Category: Sewell, A.K]]
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
-[[Category: Rizkallah, P.J]]
+== Function ==
+[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bulek, A M]]
+[[Category: Cole, D K]]
+[[Category: Rizkallah, P J]]
+[[Category: Sewell, A K]]
+[[Category: 1e6-tcr]]
+[[Category: Cross-reactivity]]
+[[Category: Hla-a02]]
+[[Category: Immune system]]
+[[Category: Immuno]]