Nitroreductase: Difference between revisions
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{{STRUCTURE_1f5v| PDB=1f5v | SIZE=400| SCENE= |right|CAPTION=E. coli nitroreductase dimer containing FMN, [[1f5v]] }} | {{STRUCTURE_1f5v| PDB=1f5v | SIZE=400| SCENE= |right|CAPTION=E. coli nitroreductase dimer containing FMN, [[1f5v]] }} | ||
== Function == | |||
'''Nitroreductase''' (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO<sub>2</sub> group. The NO<sub>2</sub> group is reduced to hydroxylamine<ref>PMID:11491290</ref>. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. | |||
== Relevance == | |||
The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy. | |||
'''Nitroreductase''' (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO<sub>2</sub> group. The NO<sub>2</sub> group is reduced to hydroxylamine. NR | |||
==3D structures of nitroreductase== | ==3D structures of nitroreductase== | ||
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**[[2wzw]] - MsNR + NADPH | **[[2wzw]] - MsNR + NADPH | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
