1ij9: Difference between revisions

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|ACTIVITY=  
|ACTIVITY=  
|GENE=  
|GENE=  
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij9 OCA], [http://www.ebi.ac.uk/pdbsum/1ij9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ij9 RCSB]</span>
}}
}}


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==Overview==
==Overview==
An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.
An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.
==Disease==
Known diseases associated with this structure: CRASH syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], Corpus callosum, partial agenesis of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], Hydrocephalus due to aqueductal stenosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], Hydrocephalus with Hirschsprung disease and cleft palate OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], Hydrocephalus with congenital idiopathic intestinal pseudoobstruction OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], MASA syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]]


==About this Structure==
==About this Structure==
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[[Category: integrin solvation]]
[[Category: integrin solvation]]


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