5b3j: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5b3j is ~~ON HOLD until Paper Publication~~

==Activation of NMDA receptors and the mechanism of inhibition by ifenprodil==

~~Authors~~: ~~Tajima~~, N., ~~Karakas~~, E., ~~Grant, T~~.~~, Simorowski, N~~.~~, Diaz~~-~~Avalos, R~~., ~~Grigorieff, N~~., ~~Furukawa, H~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5b3j]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B3J FirstGlance]. <br>

~~Description:~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b3j OCA], [http://pdbe.org/5b3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b3j RCSB], [http://www.ebi.ac.uk/pdbsum/5b3j PDBsum]</span></td></tr>

[[Category: ~~Tajima~~, N]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT]] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

__TOC__

</StructureSection>

[[Category: Mus musculus]]

[[Category: Diaz-Avalos, R]]

[[Category: Furukawa, H]]

~~[[Category: Diaz-Avalos, R]]~~

[[Category: Grant, T]]

[[Category: Grigorieff, N]]

[[Category: Karakas, E]]

[[Category: Simorowski, N]]

[[Category: ~~Karakas~~, E]]

[[Category: Tajima, N]]

[[Category: ~~Grigorieff, N~~]]

[[Category: Nmda receptor]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5b3j is ON HOLD  until Paper Publication
+==Activation of NMDA receptors and the mechanism of inhibition by ifenprodil==
+<StructureSection load='5b3j' size='340' side='right' caption='[[5b3j]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors: Tajima, N., Karakas, E., Grant, T., Simorowski, N., Diaz-Avalos, R., Grigorieff, N., Furukawa, H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5b3j]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B3J FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b3j OCA], [http://pdbe.org/5b3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b3j RCSB], [http://www.ebi.ac.uk/pdbsum/5b3j PDBsum]</span></td></tr>
-[[Category: Tajima, N]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT]] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Mus musculus]]
+[[Category: Diaz-Avalos, R]]
 [[Category: Furukawa, H]]
-[[Category: Diaz-Avalos, R]]
 [[Category: Grant, T]]
+[[Category: Grigorieff, N]]
+[[Category: Karakas, E]]
 [[Category: Simorowski, N]]
-[[Category: Karakas, E]]
+[[Category: Tajima, N]]
-[[Category: Grigorieff, N]]
+[[Category: Nmda receptor]]
+[[Category: Transport protein]]