5aul: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5aul is ~~ON HOLD until Paper Publication~~

==PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex==

~~Authors~~: ~~Inaba~~, S., ~~Numoto~~, N., ~~Morii~~, H., ~~Ikura~~, T., ~~Oda~~, M., ~~Ito~~, N.

== Structural highlights ==

<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUL FirstGlance].

~~Description: PI3K p85 C-terminal SH2 domain~~/~~CD28-derived peptide complex~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3wa4|3wa4]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [http://pdbe.org/5aul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [http://www.ebi.ac.uk/pdbsum/5aul PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref> [[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

== References ==

__TOC__

</StructureSection>

[[Category: Ikura, T]]

[[Category: Inaba, S]]

[[Category: Ito, N]]

[[Category: Morii, H]]

[[Category: Numoto, N]]

[[Category: Oda, M]]

[[Category: ~~Morii, H~~]]

[[Category: Antigen]]

[[Category: ~~Ito, N~~]]

[[Category: Phosphopeptide]]

[[Category: ~~Ikura, T~~]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5aul is ON HOLD  until Paper Publication
+==PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex==
+<StructureSection load='5aul' size='340' side='right' caption='[[5aul]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
-Authors: Inaba, S., Numoto, N., Morii, H., Ikura, T., Oda, M., Ito, N.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5aul]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUL FirstGlance]. <br>
-Description: PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wa4|3wa4]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aul OCA], [http://pdbe.org/5aul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aul RCSB], [http://www.ebi.ac.uk/pdbsum/5aul PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref>  [[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ikura, T]]
 [[Category: Inaba, S]]
+[[Category: Ito, N]]
+[[Category: Morii, H]]
 [[Category: Numoto, N]]
 [[Category: Oda, M]]
-[[Category: Morii, H]]
+[[Category: Antigen]]
-[[Category: Ito, N]]
+[[Category: Phosphopeptide]]
-[[Category: Ikura, T]]
+[[Category: Signaling protein]]