Formate dehydrogenase

<StructureSection load='2nad' size='450' side='right' scene= caption='NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, 2nad'>

Formate dehydrogenase (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe₄S₄ center and then to cytochrome. The Mo-dependent FDH-H from E. coli contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe₄S₄.

3D structure of formate dehydrogenase

Updated on 07-June-2016

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• NAD-dependent FDH
  • 2nac, 2go1 – PsFDH – Pseudomonas
    
  • 2fss – CbFDH – Candida boidinii
    
  • 2j6i – CbFDH C terminal (mutant)
    
  • 3fn4 - MoFDH – Moraxella
    
  • 3naq, 3jtm – ArFDH – Arabidopsis thaliana
    
  • 2nad – PsFDH + NAD
    
  • 2gug – PsFDH + formate
    
  • 2gsd – MoFDH + NAD + N3
    
  • 3n7u - ArFDH + NAD + N3
    
  • 3wr5 – FDH + NAD – Thiobacillus
    
• Mo-dependent FDH
  • 1aa6, 1fdo, 2iv2 – EcFDH-H + Fe4S4 + MGD – Escherichia coli
    
  • 1fdi - EcFDH-H + Fe4S4 + NO2 + MGD
    
  • 1kqf - EcFDH-N + Fe4S4 + protoporphyrin + MGD
    
  • 1kqg - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD
    
  • 1h0h - FDH + Fe4S4 +MGD – Desulfovibrio gigas

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