Nucleoside diphosphate kinase: Difference between revisions
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<StructureSection load='1ucn' size='350' side='right' caption='Human nucleoside diphosphate kinase complex with ADP, phosphate and Ca+2 ion (green) (PDB entry [[1ucn]])' scene=''> | <StructureSection load='1ucn' size='350' side='right' caption='Human nucleoside diphosphate kinase trimer complex with ADP, phosphate, TRIS and Ca+2 ion (green) (PDB entry [[1ucn]])' scene=''> | ||
== Function == | == Function == | ||
'''Nucleoside diphosphate kinase''' (NDK) catalyzes the exchange of phosphate between nucleoside triphosphate and nucleoside diphosphate. This reaction is a multi-step reaction which is | '''Nucleoside diphosphate kinase''' (NDK) catalyzes the exchange of phosphate between nucleoside triphosphate and nucleoside diphosphate. This reaction is a multi-step reaction which is used for the synthesis of nucleoside triphosphates other than ATP<ref>PMID:11768305</ref>. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerization. | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
The NDK-adenine structure shows the two reaction products: ADP and phosphate<ref>PMID:12972261</ref>. | |||
</StructureSection> | </StructureSection> | ||
