P63: Difference between revisions

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'''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development. One isoform of P63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions.

== Function ==

~~== Function ==~~

'''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development<ref>PMID:10594758</ref>. One isoform of P63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions.

== Disease ==

Mutations in P63 result in cleft lip or palate syndromes, split hand/foot malformation or ectodermal dysplasia.

Mutations in P63 result in cleft lip or palate syndromes, split hand/foot malformation or ectodermal dysplasia<ref>PMID:16740912</ref>, <ref>PMID:23407076</ref>.

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 <StructureSection load='3us0' size='340' side='right' caption='P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey)  (PDB code [[3us0]])' scene=''>
-'''P63''' is a tumor protein belonging to the P53 family.  It is a multi-isoform protein required for epidermal development.  One isoform of P63 is involved in skin development and stem/progenitor cell regulation.  Another isoform functions in apoptosis.  P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain.  In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains.  The SAM domain is involved in protein-protein interactions.
+== Function ==
-== Function ==
+'''P63''' is a tumor protein belonging to the P53 family.  It is a multi-isoform protein required for epidermal development<ref>PMID:10594758</ref>.  One isoform of P63 is involved in skin development and stem/progenitor cell regulation.  Another isoform functions in apoptosis.  P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain.  In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains.  The SAM domain is involved in protein-protein interactions.
 == Disease ==
-Mutations in P63 result in cleft lip or palate syndromes, split hand/foot malformation or ectodermal dysplasia.
+Mutations in P63 result in cleft lip or palate syndromes, split hand/foot malformation or ectodermal dysplasia<ref>PMID:16740912</ref>, <ref>PMID:23407076</ref>.
 == Relevance ==