5dcy

Iridoid synthase G150A mutant from Catharanthus roseus - binary complex with NADP+

spinqualitylabelsall models 5dcy, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5dcy is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, NAP, PGE Activity: Iridoid synthase, with EC number 1.3.1.99 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Publication Abstract from PubMed The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5beta-reductase are highlighted. Structural determinants of reductive terpene cyclization in iridoid biosynthesis.,Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE Nat Chem Biol. 2015 Nov 9. doi: 10.1038/nchembio.1955. PMID:26551396 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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