4uhl: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4uhl is ~~ON HOLD until Paper Publication~~

==HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN P1 SPACE GROUP==

~~Authors~~: ~~Hargrove~~, T.Y., ~~Wawrzak~~, Z., ~~I Lepesheva~~, G.

== Structural highlights ==

<table><tr><td colspan='2'>[[4uhl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHL OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHL FirstGlance].

~~Description~~: ~~HUMAN STEROL~~ 14-~~ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN P1 SPACE GROUP~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VFV:N-[(1R)-1-(3,4-DIFLUOROBIPHENYL-4-YL)-2-(1H-IMIDAZOL-1-YL)ETHYL]-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZAMIDE'>VFV</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4uhi|4uhi]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhl OCA], [http://pdbe.org/4uhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhl RCSB], [http://www.ebi.ac.uk/pdbsum/4uhl PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN]] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

__TOC__

</StructureSection>

[[Category: Sterol 14-demethylase]]

[[Category: Hargrove, T Y]]

[[Category: Lepesheva, G I]]

[[Category: Wawrzak, Z]]

[[Category: ~~Hargrove, T.Y~~]]

[[Category: Cyp51]]

[[Category: ~~I Lepesheva, G~~]]

[[Category: Cytochrome p450]]

[[Category: Cytochrome p450 fold]]

[[Category: Endoplasmic reticulum]]

[[Category: Eukaryotic membrane]]

[[Category: Monooxygenase]]

[[Category: Oxidoreductase]]

[[Category: Sterol biosynthesis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4uhl is ON HOLD  until Paper Publication
+==HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN P1 SPACE GROUP==
+<StructureSection load='4uhl' size='340' side='right' caption='[[4uhl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Hargrove, T.Y., Wawrzak, Z., I Lepesheva, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4uhl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHL FirstGlance]. <br>
-Description: HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN P1 SPACE GROUP
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VFV:N-[(1R)-1-(3,4-DIFLUOROBIPHENYL-4-YL)-2-(1H-IMIDAZOL-1-YL)ETHYL]-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZAMIDE'>VFV</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhi|4uhi]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhl OCA], [http://pdbe.org/4uhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhl RCSB], [http://www.ebi.ac.uk/pdbsum/4uhl PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN]] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
+__TOC__
+</StructureSection>
+[[Category: Sterol 14-demethylase]]
+[[Category: Hargrove, T Y]]
+[[Category: Lepesheva, G I]]
 [[Category: Wawrzak, Z]]
-[[Category: Hargrove, T.Y]]
+[[Category: Cyp51]]
-[[Category: I Lepesheva, G]]
+[[Category: Cytochrome p450]]
+[[Category: Cytochrome p450 fold]]
+[[Category: Endoplasmic reticulum]]
+[[Category: Eukaryotic membrane]]
+[[Category: Monooxygenase]]
+[[Category: Oxidoreductase]]
+[[Category: Sterol biosynthesis]]