5acb: Difference between revisions
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==Crystal Structure of the Human Cdk12-Cyclink Complex== | |||
<StructureSection load='5acb' size='340' side='right' caption='[[5acb]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5acb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ACB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ACB FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5I1:N-[4-[(3R)-3-[[5-CHLORANYL-4-(1H-INDOL-3-YL)PYRIMIDIN-2-YL]AMINO]PIPERIDIN-1-YL]CARBONYLPHENYL]-4-(DIMETHYLAMINO)BUTANAMIDE'>5I1</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5acb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5acb OCA], [http://pdbe.org/5acb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5acb RCSB], [http://www.ebi.ac.uk/pdbsum/5acb PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cyclin-dependent kinase]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Bullock, A]] | [[Category: Bullock, A]] | ||
[[Category: Burgess-Brown, N]] | [[Category: Burgess-Brown, N]] | ||
[[Category: Carpenter, E P]] | |||
[[Category: Chalk, R]] | [[Category: Chalk, R]] | ||
[[Category: | [[Category: Clarke, S E.Dixon]] | ||
[[Category: Delft, F von]] | |||
[[Category: Edwards, A M]] | |||
[[Category: Elkins, J M]] | |||
[[Category: Fitzpatrick, F]] | [[Category: Fitzpatrick, F]] | ||
[[Category: Goubin, S]] | |||
[[Category: Kopec, J]] | [[Category: Kopec, J]] | ||
[[Category: | [[Category: Mackenzie, A]] | ||
[[Category: Mahajan, P]] | [[Category: Mahajan, P]] | ||
[[Category: | [[Category: Pike, A C.W]] | ||
[[Category: Strain-Damerell, C]] | |||
[[Category: Tallant, C]] | [[Category: Tallant, C]] | ||
[[Category: | [[Category: Wiggers, H]] | ||
[[Category: | [[Category: Transferase]] | ||
Revision as of 22:21, 20 June 2016
Crystal Structure of the Human Cdk12-Cyclink Complex
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