5b2j: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5b2j ~~is ON HOLD until Paper Publication~~

==Human nucleosome containing CpG methylated DNA==

~~Authors~~: ~~Fujii, Y~~.~~, Wakamori, M~~.~~, Umehara, T~~.~~, Yokoyama, S~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5b2j]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B2J OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B2J FirstGlance].

~~Description~~: ~~Human nucleosome containing CpG methylated DNA~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>

[[~~Category~~: ~~Wakamori~~, M]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5b2i|5b2i]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b2j OCA], [http://pdbe.org/5b2j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b2j RCSB], [http://www.ebi.ac.uk/pdbsum/5b2j PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Fujii, Y]]

[[Category: Umehara, T]]

[[Category: Wakamori, M]]

[[Category: Yokoyama, S]]

[[Category: Chromatin]]

[[Category: Epigenetic]]

[[Category: Histone]]

[[Category: Transcription]]

[[Category: Transcription-dna complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5b2j is ON HOLD  until Paper Publication
+==Human nucleosome containing CpG methylated DNA==
+<StructureSection load='5b2j' size='340' side='right' caption='[[5b2j]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors: Fujii, Y., Wakamori, M., Umehara, T., Yokoyama, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5b2j]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B2J FirstGlance]. <br>
-Description: Human nucleosome containing CpG methylated DNA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
-[[Category: Wakamori, M]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5b2i|5b2i]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b2j OCA], [http://pdbe.org/5b2j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b2j RCSB], [http://www.ebi.ac.uk/pdbsum/5b2j PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>   Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Fujii, Y]]
 [[Category: Umehara, T]]
+[[Category: Wakamori, M]]
 [[Category: Yokoyama, S]]
+[[Category: Chromatin]]
+[[Category: Epigenetic]]
+[[Category: Histone]]
+[[Category: Transcription]]
+[[Category: Transcription-dna complex]]