5f4q: Difference between revisions
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==Crystal structure of the human egg surface protein Juno== | |||
<StructureSection load='5f4q' size='340' side='right' caption='[[5f4q]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5f4q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F4Q FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f4e|5f4e]], [[5f4t|5f4t]], [[5f4v|5f4v]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f4q OCA], [http://pdbe.org/5f4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f4q RCSB], [http://www.ebi.ac.uk/pdbsum/5f4q PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/JUNO_HUMAN JUNO_HUMAN]] Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.[UniProtKB:Q9EQF4] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aydin, H]] | |||
[[Category: Lee, J E]] | |||
[[Category: Sultana, A]] | [[Category: Sultana, A]] | ||
[[Category: | [[Category: Cell adhesion]] | ||
[[Category: | [[Category: Cysteine-rich]] | ||
[[Category: Glycoprotein]] | |||
[[Category: Membrane-bound]] | |||
[[Category: Receptor]] | |||
Revision as of 22:25, 20 June 2016
Crystal structure of the human egg surface protein Juno
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