Phage integrase: Difference between revisions

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Michal Harel (talk | contribs)
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{{STRUCTURE_1z1g|  PDB=1z1g  | SIZE=400| SCENE=Phage_integrase/Cv/1 |right|CAPTION= Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) [[1z1g]] }}
{{STRUCTURE_1z1g|  PDB=1z1g  | SIZE=400| SCENE=Phage_integrase/Cv/1 |right|CAPTION= Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) [[1z1g]] }}


'''Phage integrase''' (PIN) mediate recombination between DNA recognition sequences - the phage attP and the bacterial attB.  The Tyrosine family PIN uses a catalytic tyrosine to mediate strand cleavage while the Serine family PIN uses a serine residue.  The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.
'''Phage integrase''' (PIN) mediates recombination between DNA recognition sequences - the phage attachment site attP and the bacterial attachment site attB<ref>PMID:14687564</ref>.  The '''Tyrosine family PIN''' uses a catalytic tyrosine to mediate strand cleavage while the '''Serine family PIN''' uses a serine residue.  The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.
 
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== 3D Structures of phage integrase ==
== 3D Structures of phage integrase ==
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[[1aih]] - PIN catalytic core domain – Haemophilus phage HP1<br />
[[1aih]] - PIN catalytic core domain – Haemophilus phage HP1<br />
[[2khv]], [[2kj5]] – PIN residues 102-199 – ''Nitrosospira multiformis'' - NMR
[[2khv]], [[2kj5]] – PIN residues 102-199 – ''Nitrosospira multiformis'' - NMR
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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