5c5b: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5c5b is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal Structure of Human APPL BAR-PH Heterodimer==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5c5b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5B FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5b OCA], [http://pdbe.org/5c5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5b RCSB], [http://www.ebi.ac.uk/pdbsum/5c5b PDBsum]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/DP13B_HUMAN DP13B_HUMAN]] A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2.

== Function ==

[[http://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref> [[http://www.uniprot.org/uniprot/DP13B_HUMAN DP13B_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:15016378</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Chen, B]]

[[Category: Chen, Y J]]

[[Category: Heterodimer]]

[[Category: Protein transport]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5c5b is ON HOLD  until Paper Publication
+==Crystal Structure of Human APPL BAR-PH Heterodimer==
+<StructureSection load='5c5b' size='340' side='right' caption='[[5c5b]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5c5b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5B FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5b OCA], [http://pdbe.org/5c5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5b RCSB], [http://www.ebi.ac.uk/pdbsum/5c5b PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/DP13B_HUMAN DP13B_HUMAN]] A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2.
+== Function ==
+[[http://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>  [[http://www.uniprot.org/uniprot/DP13B_HUMAN DP13B_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:15016378</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chen, B]]
+[[Category: Chen, Y J]]
+[[Category: Heterodimer]]
+[[Category: Protein transport]]