5eso: Difference between revisions

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'''Unreleased structure'''


The entry 5eso is ON HOLD  until Paper Publication
==Crystal Structure of M. tuberculosis MenD with ThDP, Mg2+ and Isochorismate bound==
 
<StructureSection load='5eso' size='340' side='right' caption='[[5eso]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5eso]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ESO FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ISC:(5S,6S)-5-[(1-CARBOXYETHENYL)OXY]-6-HYDROXYCYCLOHEXA-1,3-DIENE-1-CARBOXYLIC+ACID'>ISC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDP:THIAMIN+DIPHOSPHATE'>TDP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5erx|5erx]], [[5ery|5ery]], [[5esd|5esd]], [[5esu|5esu]], [[5ess|5ess]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid_synthase 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.9 2.2.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eso OCA], [http://pdbe.org/5eso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eso RCSB], [http://www.ebi.ac.uk/pdbsum/5eso PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MEND_MYCTU MEND_MYCTU]] Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
__TOC__
</StructureSection>
[[Category: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase]]
[[Category: Baker, E N]]
[[Category: Bashiri, G]]
[[Category: Bulloch, E M.M]]
[[Category: Jirgis, E N.M]]
[[Category: Johnston, J M]]
[[Category: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase]]
[[Category: Menaquinone biosynthesis]]
[[Category: Mend]]
[[Category: Pyruvate oxidase family]]
[[Category: Thiamin-diphosphate dependent enzyme]]
[[Category: Transferase]]
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