5jcp: Difference between revisions
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==RhoGAP domain of ARAP3 in complex with RhoA in the transition state== | |||
<StructureSection load='5jcp' size='340' side='right' caption='[[5jcp]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jcp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JCP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JCP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jcp OCA], [http://pdbe.org/5jcp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jcp RCSB], [http://www.ebi.ac.uk/pdbsum/5jcp PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ARAP3_HUMAN ARAP3_HUMAN]] Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.<ref>PMID:11804589</ref> <ref>PMID:15569923</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bao, H]] | |||
[[Category: Jiang, Y]] | |||
[[Category: Li, F]] | |||
[[Category: Shi, Y]] | |||
[[Category: Tang, Y]] | |||
[[Category: Wang, C]] | |||
[[Category: Wang, N]] | |||
[[Category: Wu, J]] | |||
[[Category: Arap3]] | |||
[[Category: Hydrolase]] | |||
[[Category: Rhoa]] | |||
[[Category: Rhogap]] | |||
[[Category: Signaling protein]] | |||
Revision as of 23:28, 23 June 2016
RhoGAP domain of ARAP3 in complex with RhoA in the transition state
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