Plasminogen: Difference between revisions
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{{STRUCTURE_1qrz| PDB=1qrz | SIZE=400| SCENE= |right|CAPTION=Human plasmin catalytic domain tetramer, [[1qrz]] }} | {{STRUCTURE_1qrz| PDB=1qrz | SIZE=400| SCENE= |right|CAPTION=Human plasmin catalytic domain tetramer, [[1qrz]] }} | ||
== Function == | |||
'''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The kringle domain folds into a large loop containing 3 disulfide bonds. The kringle domain is important in protein-protein interaction with blood coagulation factors. | |||
== Disease == | |||
PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces<ref>PMID:19141167</ref>. | |||
== 3D Structures of plasminogen == | == 3D Structures of plasminogen == | ||
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**[[3uir]] – hPLN + textilinin-1<br /> | **[[3uir]] – hPLN + textilinin-1<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:22, 4 July 2016
Function
Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The kringle domain folds into a large loop containing 3 disulfide bonds. The kringle domain is important in protein-protein interaction with blood coagulation factors.
Disease
PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces[1].
3D Structures of plasminogen
Updated on 04-July-2016
- ↑ Mehta R, Shapiro AD. Plasminogen deficiency. Haemophilia. 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID:19141167 doi:https://dx.doi.org/10.1111/j.1365-2516.2008.01825.x
