Pre-mRNA-splicing factor: Difference between revisions
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<StructureSection load='3zef' size='350' side='right' caption='Yeast pre-mRNA-splicing factor 8 complex with AAR2 (PDB entry [[3zef]])' scene=''> | |||
== Function == | == Function == | ||
'''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing<ref>PMID:10394358</ref>. | '''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing<ref>PMID:10394358</ref>. | ||
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== Disease == | == Disease == | ||
Mutations in Prp8 and Prp31 cause retinitis pigmentosa<ref>PMID:11468273</ref>. | Mutations in Prp8 and Prp31 cause retinitis pigmentosa<ref>PMID:11468273</ref>. | ||
== Structural highlights == | |||
</StructureSection> | |||
== 3D Structures of pre-mRNA splicing factors == | == 3D Structures of pre-mRNA splicing factors == | ||
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**[[4ilj]], [[4jk8]], [[4jka]], [[4jkb]], [[4jkc]], [[4jkd]], [[4jke]], [[4jkf]], [[4jkg]], [[4jkh]] - yPrp RNA-binding domain (mutant)<br /> | **[[4ilj]], [[4jk8]], [[4jka]], [[4jkb]], [[4jkc]], [[4jkd]], [[4jke]], [[4jkf]], [[4jkg]], [[4jkh]] - yPrp RNA-binding domain (mutant)<br /> | ||
**[[3zef]], [[4i43]] – yPrp + A1 cistron-splicing factor AAR2<br /> | **[[3zef]], [[4i43]] – yPrp + A1 cistron-splicing factor AAR2<br /> | ||
**[[2og4]], [[ | **[[2og4]], [[3sbg]] - yPrp Jab1/MPN domain<br /> | ||
**[[4bgd]] – yPrp Jab1/MPN domain + pre-mRNA-splicing helicase BRR2<br /> | **[[4bgd]] – yPrp Jab1/MPN domain + pre-mRNA-splicing helicase BRR2<br /> | ||
**[[4kit]] – yPrp Jab1/MPN domain + U5 small nuclear ribonucleoprotein helicase <br /> | **[[4kit]] – yPrp Jab1/MPN domain + U5 small nuclear ribonucleoprotein helicase <br /> | ||
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**[[3e9l]], [[3enb]] – hPrp endonuclease domain<br /> | **[[3e9l]], [[3enb]] – hPrp endonuclease domain<br /> | ||
**[[2p8r]] – CePrp C terminal (mutant) – ''Caenorhabditis elegans''<br /> | **[[2p8r]] – CePrp C terminal (mutant) – ''Caenorhabditis elegans''<br /> | ||
*[[2p87]] – CePrp C terminal <br /> | **[[2p87]] – CePrp C terminal <br /> | ||
*Pre-mRNA-splicing factor 9 | *Pre-mRNA-splicing factor 9 | ||
