5i2z: Difference between revisions
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==Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated triazole-linked carboxylate chelating water-soluble inhibitor (DC24).== | |||
<StructureSection load='5i2z' size='340' side='right' caption='[[5i2z]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5i2z]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I2Z FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=V24:N-[([1,1-BIPHENYL]-4-YL)SULFONYL]-N-({1-[3,4,6-TRI-O-ACETYL-2-(ACETYLAMINO)-2-DEOXY-BETA-D-GLUCOPYRANOSYL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-D-VALINE'>V24</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iol|5iol]], [[5i12|5i12]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2z OCA], [http://pdbe.org/5i2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2z RCSB], [http://www.ebi.ac.uk/pdbsum/5i2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2z ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Macrophage elastase]] | |||
[[Category: Ciccone, L]] | |||
[[Category: Cuffaro, D]] | |||
[[Category: Rosalia, L]] | |||
[[Category: Rossello, A]] | [[Category: Rossello, A]] | ||
[[Category: Stura, E | [[Category: Stura, E A]] | ||
[[Category: Tepshi, L]] | [[Category: Tepshi, L]] | ||
[[Category: | [[Category: Complex]] | ||
[[Category: | [[Category: Glycoconjugate]] | ||
[[Category: Hydrolase]] | |||
[[Category: Inhibitor]] | |||
[[Category: Metalloprotease]] | |||
Revision as of 03:00, 13 July 2016
Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated triazole-linked carboxylate chelating water-soluble inhibitor (DC24).
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