2n4y: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome== | |||
<StructureSection load='2n4y' size='340' side='right' caption='[[2n4y]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n4y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N4Y FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4y OCA], [http://pdbe.org/2n4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n4y RCSB], [http://www.ebi.ac.uk/pdbsum/2n4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4y ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The long terminal repeat (LTR) of the proviral human immunodeficiency virus (HIV)-1 genome is integral to virus transcription and host cell infection. The guanine-rich U3 region within the LTR promoter, previously shown to form G-quadruplex structures, represents an attractive target to inhibit HIV transcription and replication. In this work, we report the structure of a biologically relevant G-quadruplex within the LTR promoter region of HIV-1. The guanine-rich sequence designated LTR-IV forms a well-defined structure in physiological cationic solution. The nuclear magnetic resonance (NMR) structure of this sequence reveals a parallel-stranded G-quadruplex containing a single-nucleotide thymine bulge, which participates in a conserved stacking interaction with a neighboring single-nucleotide adenine loop. Transcription analysis in a HIV-1 replication competent cell indicates that the LTR-IV region may act as a modulator of G-quadruplex formation in the LTR promoter. Consequently, the LTR-IV G-quadruplex structure presented within this work could represent a valuable target for the design of HIV therapeutics. | |||
Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome.,De Nicola B, Lech CJ, Heddi B, Regmi S, Frasson I, Perrone R, Richter SN, Phan AT Nucleic Acids Res. 2016 Jun 13. pii: gkw432. PMID:27298260<ref>PMID:27298260</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 2n4y" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: DeNicola, B]] | |||
[[Category: Frasson, I]] | |||
[[Category: Heddi, B]] | [[Category: Heddi, B]] | ||
[[Category: Lech, C J]] | |||
[[Category: Perrone, R]] | |||
[[Category: Phan, A T]] | |||
[[Category: Regmi, S]] | [[Category: Regmi, S]] | ||
[[Category: | [[Category: Richter, S N]] | ||
[[Category: | [[Category: Dna]] | ||
[[Category: | [[Category: G-quadruplex]] | ||
[[Category: | [[Category: Hiv-1]] | ||
[[Category: Long terminal repeat]] | |||
Revision as of 10:11, 13 July 2016
Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome
| ||||||||||||
