5a4k: Difference between revisions
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==Crystal structure of the R139W variant of human NAD(P)H:quinone oxidoreductase== | |||
<StructureSection load='5a4k' size='340' side='right' caption='[[5a4k]], [[Resolution|resolution]] 2.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5a4k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4K FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | |||
[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(P)H_dehydrogenase_(quinone) NAD(P)H dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.2 1.6.5.2] </span></td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4k OCA], [http://pdbe.org/5a4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4k RCSB], [http://www.ebi.ac.uk/pdbsum/5a4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4k ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[[ | == Function == | ||
[[http://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gruber, K]] | [[Category: Gruber, K]] | ||
[[Category: Gudipati, V]] | [[Category: Gudipati, V]] | ||
[[Category: Lienhart, W | [[Category: Lienhart, W D]] | ||
[[Category: Macheroux, P]] | [[Category: Macheroux, P]] | ||
[[Category: Rantase, D | [[Category: Rantase, D M]] | ||
[[Category: Strandback, E]] | |||
[[Category: Uhl, M K]] | |||
[[Category: Zangger, K]] | |||
[[Category: Drug metabolism]] | |||
[[Category: Fad]] | |||
[[Category: Flavoprotein]] | |||
[[Category: Nqo1]] | |||
[[Category: Oxidative stress]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Quinone reductase]] | |||
[[Category: Single amino acid exchange]] | |||
Revision as of 10:16, 13 July 2016
Crystal structure of the R139W variant of human NAD(P)H:quinone oxidoreductase
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