5bxo: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5bxo is ~~ON HOLD~~ ~~until Paper Publication~~

==Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5bxo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BXO OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BXO FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4XP:4,4-PROPANE-1,3-DIYLBIS(1-METHYL-1H-1,2,3-TRIAZOLE)'>4XP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bxo OCA], [http://pdbe.org/5bxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bxo RCSB], [http://www.ebi.ac.uk/pdbsum/5bxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bxo ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Fischer, G]]

[[Category: Hyvonen, M]]

[[Category: Itzhaki, L]]

[[Category: Xu, W]]

[[Category: Ankyrin-repeat domain]]

[[Category: Protein-protein interaction]]

[[Category: Stapled peptide]]

[[Category: Tankyrase]]

[[Category: Transferase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5bxo is ON HOLD  until Paper Publication
+==Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3==
+<StructureSection load='5bxo' size='340' side='right' caption='[[5bxo]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bxo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BXO FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4XP:4,4-PROPANE-1,3-DIYLBIS(1-METHYL-1H-1,2,3-TRIAZOLE)'>4XP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bxo OCA], [http://pdbe.org/5bxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bxo RCSB], [http://www.ebi.ac.uk/pdbsum/5bxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bxo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fischer, G]]
+[[Category: Hyvonen, M]]
+[[Category: Itzhaki, L]]
+[[Category: Xu, W]]
+[[Category: Ankyrin-repeat domain]]
+[[Category: Protein-protein interaction]]
+[[Category: Stapled peptide]]
+[[Category: Tankyrase]]
+[[Category: Transferase]]