5c58: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 5c58 is ON HOLD~~

==A double mutant of serratia marcescens hemophore receptor HasR in complex with its hemophore HasA and heme==

~~Authors: Becker, S., Diederichs, K., Welte, W.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5c58]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C58 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C58 FirstGlance].

~~Description:~~ A double mutant of serratia marcescens hemophore receptor HasR in complex with its hemophore HasA and heme

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3csl|3csl]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c58 OCA], [http://pdbe.org/5c58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c58 RCSB], [http://www.ebi.ac.uk/pdbsum/5c58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c58 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HASA_SERMA HASA_SERMA]] Can bind free heme and also acquire it from hemoglobin. Conveys heme from hemoglobin to the HasR receptor which releases it into the bacterium. HasR alone can take up heme but the synergy between HasA and HasR increases heme uptake 100-fold.<ref>PMID:7937909</ref> <ref>PMID:9171402</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Becker, S]]

[[Category: Diederichs, K]]

[[Category: Welte, W]]

[[Category: Heme transfer]]

[[Category: Outer membrane receptor]]

[[Category: Transport protein]]

[[Category: Transporter complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5c58 is ON HOLD
+==A double mutant of serratia marcescens hemophore receptor HasR in complex with its hemophore HasA and heme==
+<StructureSection load='5c58' size='340' side='right' caption='[[5c58]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
-Authors: Becker, S., Diederichs, K., Welte, W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5c58]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C58 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C58 FirstGlance]. <br>
-Description: A double mutant of serratia marcescens hemophore receptor HasR in complex with its hemophore HasA and heme
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3csl|3csl]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c58 OCA], [http://pdbe.org/5c58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c58 RCSB], [http://www.ebi.ac.uk/pdbsum/5c58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c58 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HASA_SERMA HASA_SERMA]] Can bind free heme and also acquire it from hemoglobin. Conveys heme from hemoglobin to the HasR receptor which releases it into the bacterium. HasR alone can take up heme but the synergy between HasA and HasR increases heme uptake 100-fold.<ref>PMID:7937909</ref> <ref>PMID:9171402</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Becker, S]]
 [[Category: Diederichs, K]]
 [[Category: Welte, W]]
+[[Category: Heme transfer]]
+[[Category: Outer membrane receptor]]
+[[Category: Transport protein]]
+[[Category: Transporter complex]]