5h9p: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5h9p is ~~ON HOLD~~

==Crystal Structure of Human Galectin-3 CRD in Complex with TD139==

~~Authors~~: ~~Hsieh~~, T.J., ~~Lin~~, H.Y., ~~Lin~~, C.H.

== Structural highlights ==

<table><tr><td colspan='2'>[[5h9p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9P OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H9P FirstGlance].

~~Description~~: ~~Crystal Structure~~ of ~~Human Galectin~~-~~3 CRD~~ in ~~Complex with TD139~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

[[Category: ~~Hsieh~~, ~~T.J~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9p OCA], [http://pdbe.org/5h9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9p RCSB], [http://www.ebi.ac.uk/pdbsum/5h9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9p ProSAT]</td></tr>

[[Category: Lin, H.Y]]

</table>

[[Category: ~~Lin, C.H~~]]

== Function ==

[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Hsieh, T J]]

[[Category: Lin, C H]]

[[Category: Lin, H Y]]

[[Category: Galectin]]

[[Category: Pi-arginine interaction]]

[[Category: Sugar binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5h9p is ON HOLD
+==Crystal Structure of Human Galectin-3 CRD in Complex with TD139==
+<StructureSection load='5h9p' size='340' side='right' caption='[[5h9p]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
-Authors: Hsieh, T.J., Lin, H.Y., Lin, C.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5h9p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H9P FirstGlance]. <br>
-Description: Crystal Structure of Human Galectin-3 CRD in Complex with TD139
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xbn|4xbn]], [[5h9q|5h9q]], [[5h9r|5h9r]], [[5h9s|5h9s]]</td></tr>
-[[Category: Hsieh, T.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9p OCA], [http://pdbe.org/5h9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9p RCSB], [http://www.ebi.ac.uk/pdbsum/5h9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9p ProSAT]</span></td></tr>
-[[Category: Lin, H.Y]]
+</table>
-[[Category: Lin, C.H]]
+== Function ==
+[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Hsieh, T J]]
+[[Category: Lin, C H]]
+[[Category: Lin, H Y]]
+[[Category: Galectin]]
+[[Category: Pi-arginine interaction]]
+[[Category: Sugar binding protein]]