5i3q: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5i3q is ~~ON HOLD until Paper Publication~~

==DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5i3q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3Q OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3Q FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=68E:5-[5-(3-HYDROXYPROP-1-YN-1-YL)THIOPHEN-2-YL]-4-METHOXY-2-METHYL-N-[(QUINOLIN-8-YL)SULFONYL]BENZAMIDE'>68E</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5i3p|5i3p]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3q OCA], [http://pdbe.org/5i3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3q RCSB], [http://www.ebi.ac.uk/pdbsum/5i3q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3q ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/Q6DLV0_9FLAV Q6DLV0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]

__TOC__

</StructureSection>

[[Category: Noble, C G]]

[[Category: Dengue]]

[[Category: Polymerase]]

[[Category: Transferase-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5i3q is ON HOLD  until Paper Publication
+==DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29==
+<StructureSection load='5i3q' size='340' side='right' caption='[[5i3q]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5i3q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3Q FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=68E:5-[5-(3-HYDROXYPROP-1-YN-1-YL)THIOPHEN-2-YL]-4-METHOXY-2-METHYL-N-[(QUINOLIN-8-YL)SULFONYL]BENZAMIDE'>68E</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i3p|5i3p]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3q OCA], [http://pdbe.org/5i3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3q RCSB], [http://www.ebi.ac.uk/pdbsum/5i3q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/Q6DLV0_9FLAV Q6DLV0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]
+__TOC__
+</StructureSection>
+[[Category: Noble, C G]]
+[[Category: Dengue]]
+[[Category: Polymerase]]
+[[Category: Transferase-inhibitor complex]]