5itt: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5itt is ~~ON HOLD until Paper Publication~~

==Crystal Structure of Human NEIL1 bound to duplex DNA containing THF==

~~Authors~~: ~~Zhu~~, C., Lu, L., ~~Zhang~~, J., ~~Yue~~, Z., ~~Song, J~~., ~~Zong~~, S.~~, Liu, M~~.~~, Stovicek, O~~.~~, Gao, Y~~., ~~Yi,~~ C.

== Structural highlights ==

<table><tr><td colspan='2'>[[5itt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ITT OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ITT FirstGlance].

~~Description: Crystal Structure of Human NEIL1 bound to duplex DNA containing THF~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5itt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5itt OCA], [http://pdbe.org/5itt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5itt RCSB], [http://www.ebi.ac.uk/pdbsum/5itt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5itt ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Gao, Y]]

[[Category: Liu, M]]

[[Category: ~~Zhu~~, C]]

[[Category: Lu, L]]

[[Category: ~~Zhang~~, J]]

[[Category: Song, J]]

[[Category: Stovicek, O]]

~~[[Category: Gao, Y]]~~

~~[[Category: Lu, L]]~~

[[Category: Yi, C]]

~~[[Category: Song, J]]~~

[[Category: Yue, Z]]

[[Category: Zhang, J]]

[[Category: Zhu, C]]

[[Category: Zong, S]]

[[Category: Dna binding protein-dna complex]]

[[Category: Neil1 dna glycosylase base excision repair fpg nei]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5itt is ON HOLD  until Paper Publication
+==Crystal Structure of Human NEIL1 bound to duplex DNA containing THF==
+<StructureSection load='5itt' size='340' side='right' caption='[[5itt]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
-Authors: Zhu, C., Lu, L., Zhang, J., Yue, Z., Song, J., Zong, S., Liu, M., Stovicek, O., Gao, Y., Yi, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5itt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ITT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ITT FirstGlance]. <br>
-Description: Crystal Structure of Human NEIL1 bound to duplex DNA containing THF
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5itx|5itx]], [[5ity|5ity]], [[5itq|5itq]], [[5itr|5itr]], [[5itu|5itu]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5itt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5itt OCA], [http://pdbe.org/5itt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5itt RCSB], [http://www.ebi.ac.uk/pdbsum/5itt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5itt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gao, Y]]
 [[Category: Liu, M]]
-[[Category: Zhu, C]]
+[[Category: Lu, L]]
-[[Category: Zhang, J]]
+[[Category: Song, J]]
 [[Category: Stovicek, O]]
-[[Category: Gao, Y]]
-[[Category: Lu, L]]
 [[Category: Yi, C]]
-[[Category: Song, J]]
 [[Category: Yue, Z]]
+[[Category: Zhang, J]]
+[[Category: Zhu, C]]
 [[Category: Zong, S]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Neil1 dna glycosylase base excision repair fpg nei]]