1jzn: Difference between revisions
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|PDB= 1jzn |SIZE=350|CAPTION= <scene name='initialview01'>1jzn</scene>, resolution 2.20Å | |PDB= 1jzn |SIZE=350|CAPTION= <scene name='initialview01'>1jzn</scene>, resolution 2.20Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1muq|1MUQ]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzn OCA], [http://www.ebi.ac.uk/pdbsum/1jzn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jzn RCSB]</span> | |||
}} | }} | ||
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[[Category: Walker, J R.]] | [[Category: Walker, J R.]] | ||
[[Category: Young, N M.]] | [[Category: Young, N M.]] | ||
[[Category: c-type lectin]] | [[Category: c-type lectin]] | ||
[[Category: protein-disaccharide complex]] | [[Category: protein-disaccharide complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:16 2008'' | ||
Revision as of 18:41, 30 March 2008
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| 1jzn, resolution 2.20Å | |||||||||||||
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| Ligands: | CA, CL, GAL, GLC, NA | ||||||||||||
| Related: | 1MUQ
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
crystal structure of a galactose-specific C-type lectin
Overview
Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is disulfide-bonded to a monomer in the other pentamer. The structure is the first example of that of a carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.
About this Structure
1JZN is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:15049685
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