2n4q: Difference between revisions
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The | ==Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)== | ||
<StructureSection load='2n4q' size='340' side='right' caption='[[2n4q]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n4q]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N4Q FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mv7|2mv7]], [[2lm0|2lm0]]</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4q OCA], [http://pdbe.org/2n4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n4q RCSB], [http://www.ebi.ac.uk/pdbsum/2n4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4q ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bushweller, J H]] | |||
[[Category: Kuntimaddi, A]] | |||
[[Category: Leach, B I]] | |||
[[Category: Af4]] | |||
[[Category: Af9]] | |||
[[Category: Cbx8]] | |||
[[Category: Chromobox homolog 8]] | |||
[[Category: Dot1l]] | |||
[[Category: H3k27me3]] | |||
[[Category: Hpc3]] | |||
[[Category: Idp]] | |||
[[Category: Intrinsically disordered protein]] | |||
[[Category: Leukemia]] | |||
[[Category: Mixed lineage leukemia]] | |||
[[Category: Mll]] | |||
[[Category: Mll-af9]] | |||
[[Category: Mllt3]] | |||
[[Category: Polycomb]] | |||
[[Category: Polycomb group protein]] | |||
[[Category: Prc1]] | |||
[[Category: Transcription]] | |||
Revision as of 15:23, 26 July 2016
Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)
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