4s0o: Difference between revisions
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==Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)== | |||
<StructureSection load='4s0o' size='340' side='right' caption='[[4s0o]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4s0o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0O FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s0p|4s0p]], [[1f16|1f16]]</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0o OCA], [http://pdbe.org/4s0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0o RCSB], [http://www.ebi.ac.uk/pdbsum/4s0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0o ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gavathiotis, E]] | |||
[[Category: Priyadarshi, A]] | |||
[[Category: Apoptosis]] | |||
[[Category: Apoptosis regulator]] | |||
[[Category: Autoinhibited dimer]] | |||
[[Category: Bcl-2 family protein]] | |||
Revision as of 15:23, 26 July 2016
Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)
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