5chz: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5chz is ~~ON HOLD~~ ~~until Jul 20 2017~~

==Structure of wild-type human MBD4 bound to a G:T mismatch==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5chz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CHZ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CHZ FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4ofa|4ofa]], [[4ofe|4ofe]], [[4ofh|4ofh]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5chz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5chz OCA], [http://pdbe.org/5chz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5chz RCSB], [http://www.ebi.ac.uk/pdbsum/5chz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5chz ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Lee, S]]

[[Category: Lin, Y L]]

[[Category: Ouzon-Shubeita, H]]

[[Category: Dna glycosylase]]

[[Category: G:t mismatch]]

[[Category: Hmbd4]]

[[Category: Hydrolase-dna complex]]

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-'''Unreleased structure'''
-The entry 5chz is ON HOLD  until Jul 20 2017
+==Structure of wild-type human MBD4 bound to a G:T mismatch==
+<StructureSection load='5chz' size='340' side='right' caption='[[5chz]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5chz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CHZ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ofa|4ofa]], [[4ofe|4ofe]], [[4ofh|4ofh]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5chz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5chz OCA], [http://pdbe.org/5chz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5chz RCSB], [http://www.ebi.ac.uk/pdbsum/5chz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5chz ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Lee, S]]
+[[Category: Lin, Y L]]
+[[Category: Ouzon-Shubeita, H]]
+[[Category: Dna glycosylase]]
+[[Category: G:t mismatch]]
+[[Category: Hmbd4]]
+[[Category: Hydrolase-dna complex]]