5ipk: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Structure of the R432A variant of Adeno-associated virus type 2 VLP==

The entry ~~5ipk is ON HOLD~~ ~~until Paper Publication~~

== Structural highlights ==

~~Authors~~:

<table><tr><td colspan='2'>[[5ipk]] is a 60 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IPK FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ipi|5ipi]]</td></tr>

~~Description~~:

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ipk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ipk OCA], [http://pdbe.org/5ipk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ipk RCSB], [http://www.ebi.ac.uk/pdbsum/5ipk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ipk ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Agbandje-McKenna, M]]

[[Category: Baker, T S]]

[[Category: Bennet, A]]

[[Category: Cardone, G]]

[[Category: Chen, W]]

[[Category: Chipman, P]]

[[Category: Drouin, L M]]

[[Category: Janssen, M E]]

[[Category: Lins, B]]

[[Category: McKenna, R]]

[[Category: Muzyczka, N]]

[[Category: Adeno-associated virus]]

[[Category: Dependoparvovirus]]

[[Category: Gene therapy]]

[[Category: Icosahedral]]

[[Category: R432a]]

[[Category: Virus like particle]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Large structure}}
+==Structure of the R432A variant of Adeno-associated virus type 2 VLP==
-The entry 5ipk is ON HOLD  until Paper Publication
+<StructureSection load='5ipk' size='340' side='right' caption='[[5ipk]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
+== Structural highlights ==
-Authors:
+<table><tr><td colspan='2'>[[5ipk]] is a 60 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IPK FirstGlance]. <br>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ipi|5ipi]]</td></tr>
-Description:
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ipk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ipk OCA], [http://pdbe.org/5ipk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ipk RCSB], [http://www.ebi.ac.uk/pdbsum/5ipk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ipk ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+{{Large structure}}
+== Function ==
+[[http://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Agbandje-McKenna, M]]
+[[Category: Baker, T S]]
+[[Category: Bennet, A]]
+[[Category: Cardone, G]]
+[[Category: Chen, W]]
+[[Category: Chipman, P]]
+[[Category: Drouin, L M]]
+[[Category: Janssen, M E]]
+[[Category: Lins, B]]
+[[Category: McKenna, R]]
+[[Category: Muzyczka, N]]
+[[Category: Adeno-associated virus]]
+[[Category: Dependoparvovirus]]
+[[Category: Gene therapy]]
+[[Category: Icosahedral]]
+[[Category: R432a]]
+[[Category: Virus like particle]]