Pteridine reductase: Difference between revisions
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<StructureSection load=' | <StructureSection load='2bfp' size='350' side='right' caption='Structure of pteridine reductase complex with NADPH and folate (PDB entry [[2bfp]])' scene=''> | ||
== Function == | |||
'''Pteridine reductase''' (PTR) catalyzes the reduction of 5,6,7,8-tetrahydrobiopterin (THBP) to biopterin. PTR is part of pterin and folate metabolism<ref>PMID:12651944</ref>. NADP is the hydrogen acceptor in this reduction. | |||
== Relevance == | |||
PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs. | |||
</StructureSection> | </StructureSection> | ||
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**[[3bmc]] – TbPTR1 + NADPH + folate <BR /> | **[[3bmc]] – TbPTR1 + NADPH + folate <BR /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:25, 31 July 2016
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3D structures of pteridine reductase
Updated on 31-July-2016
