Pteridine reductase

spinqualitylabelsall models Structure of pteridine reductase complex with NADPH and folate (PDB entry 2bfp) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pteridine reductase (PTR) catalyzes the reduction of 5,6,7,8-tetrahydrobiopterin (THBP) to biopterin. PTR is part of pterin and folate metabolism. NADP is the hydrogen acceptor in this reduction. Relevance PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs. Structural highlights Six residues are important for creating the active site, substrate binding or implicated in catalysis.

3D structures of pteridine reductase

Updated on 31-July-2016

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• Pteridine reductase
  • 2xox – LdPTR1 (mutant) – Leishmania donovani
    
  • 2bfo – LmPTR1 + NADPH – Leishmania major
    
• Pteridine reductase complex with inhibitor
  • 1e7w – LmPTR1 + NADPH + MTX
    
  • 1w0c – LmPTR1 + NADPH + TAQ
    
  • 1p33 – PTR1 + NADPH + MTX – Leishmania tarentolae
    
  • 1mxf – TcPTR2 + NADPH + MTX – Trypanosoma cruzi
    
  • 2c7v – TbPTR1 + NADPH + MTX – Trypanosoma brucei
    
  • 3bmn, 3bmo, 3bmq, 2wd7, 2wd8, 2vz0, 3jq6, 3jq7, 3jq8, 3jq9, 3jqa, 3jqb, 3jqc, 3jqf, 3jqd, 3jqe, 3jqg, 3gn1, 3gn2, 3mcv, 2x9g, 2x9v, 2x9n, 2yhi, 2yhu, 4cl8, 4cld, 4cle, 4clh, 4clo, 4clr, 4clx, 4cm1, 4cm3, 4cm4, 4cm5, 4cm6, 4cm7, 4cm8, 4cm9, 4cma, 4cmb, 4cmc, 4cme, 4cmg, 4cmi, 4cmj, 4cmk – TbPTR1 + NADPH + inhibitor
    
  • 2bfa, 2bfm, 3h4v – LmPTR1 + NADPH + inhibitor
    
• Pteridine reductase complex with ligand
  • 2bfp – LmPTR1 + NADPH + THBP
    
  • 2qhx – LmPTR1 + NADPH + ligand
    
  • 1e92, 2bf7 – LmPTR1 + NADPH + DHBP
    
  • 1mxh – TcPTR1 + NADPH + folate
    
  • 3bmc – TbPTR1 + NADPH + folate
    

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