Purine repressor

spinqualitylabelsall models Structure of E. coli purine processor complex with DNA (green) and guanine (PDB entry 1wet) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Purine repressor (PurR) is a member of the lac repressor family. PurP binds DNA via a highly conserved helix-turn-helix at the N terminal (DBD). PurP contains a nucleotide co-repressor binding domain as well (CBD). PurP binds to a 16-bp operator sequence and co-regulates genes which are involved in the biosynthesis of purine and pyrimidine nucleotides. Structural highlights The PurP guanine co-repressor binding site includes stacking interactions as well as hydrogen bonded ones. The DNA binding domain contains a helix-turn-helix-loop-helix motif which interacts with the DNA major groove and a hinge helix binding to to the DNA minor groove. Residue L53 interdigitates with the DNA central base pair.

3D structures of purine repressor

Updated on 31-July-2016

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• Purine repressor
  • 1pru, 1prv - EcPurR DBD – Escherichia coli - NMR
    
  • 1dbq - EcPurR CBD + Mg - NMR
    
  • 1jhz - EcPurR CBD (mutant) + Mg
    
• Purine repressor complex with DNA and nucleotide
  • 1pnr, 1bdi, 1qp0, 1qp4, 1qpz, 1qqb - EcPurR + DNA + hypoxanthine
    
  • 1bdh, 2pud, 2pug, 1vpw, 1qp7, 1qqa, 1jfs, 1jft, 1jh9 - EcPurR (mutant) + DNA + hypoxanthine
    
  • 1wet - EcPurR + DNA + guanine
    
  • 2pua - EcPurR (mutant) + DNA + methylpurine
    
  • 2pub, 2pue - EcPurR (mutant) + DNA + adenine
    
  • 2puc, 2puf - EcPurR (mutant) + DNA + guanine
    
  • 1zay - EcPurR + DNA + hypoxanthine + di-imino-purine
    

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