Sandbox 122: Difference between revisions

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Karyopherin beta 2 (kapβ2) is an importin that transports various cargo protein into the nucleus through interactions :with nucleoporins, which are proteins of the nucleopore complex (NPC). One might overlook the significance of this :protein but actually plays a crucial role in the human body by mediating transport of RNA- binding proteins involved in :transcription, RNA processing, RNA transport and translation. The structure of KAPβ is composed of

20 antiparallel helices:called HEAT repeats. These HEAT repeats contribute to kapβ2’s large superhelical shape. That form two arches: one at the :N-terminal and the other at the C- terminal. Through recognition of a nuclear localization signal (NLS) located on its :cargo, kapβ2 binds to its cargo via its C-terminal arch. Release of the cargo is mediated by RanGTP, which once bound, :modifies the shape of kapβ2. Release of the cargo is mediated once contact occurs between RanGTP and N-terminal arch of Kapβ2.

<scene name='37/372723/4oo6_rainbow_heat_repeats/1'>20 antiparallel helices</scene>:called HEAT repeats. These HEAT repeats contribute to kapβ2’s large superhelical shape. That form two arches: one at the :N-terminal and the other at the C- terminal. Through recognition of a nuclear localization signal (NLS) located on its :cargo, kapβ2 binds to its cargo via its C-terminal arch. Release of the cargo is mediated by RanGTP, which once bound, :modifies the shape of kapβ2. Release of the cargo is mediated once contact occurs between RanGTP and N-terminal arch of Kapβ2.

~~<Structure load='4OO6' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />~~

Sandbox 122: Difference between revisions

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 Karyopherin beta 2 (kapβ2) is an importin that transports various cargo protein into the nucleus through interactions :with nucleoporins,  which are proteins of the nucleopore complex (NPC). One might overlook the significance of this :protein but actually plays a crucial role in the human body by mediating transport of RNA- binding proteins involved in :transcription, RNA processing, RNA transport and translation. The structure of KAPβ is composed of
-antiparallel helices:called HEAT repeats. These HEAT repeats contribute to kapβ2’s large superhelical shape. That form two arches: one at the :N-terminal and the other at the C- terminal. Through recognition of a nuclear localization signal (NLS) located on its :cargo, kapβ2 binds to its cargo via its C-terminal arch. Release of the cargo is mediated by RanGTP, which once bound, :modifies the shape of kapβ2.  Release of the cargo is mediated once contact occurs between RanGTP and N-terminal arch of Kapβ2.
+<scene name='37/372723/4oo6_rainbow_heat_repeats/1'>20 antiparallel helices</scene>:called HEAT repeats. These HEAT repeats contribute to kapβ2’s large superhelical shape. That form two arches: one at the :N-terminal and the other at the C- terminal. Through recognition of a nuclear localization signal (NLS) located on its :cargo, kapβ2 binds to its cargo via its C-terminal arch. Release of the cargo is mediated by RanGTP, which once bound, :modifies the shape of kapβ2.  Release of the cargo is mediated once contact occurs between RanGTP and N-terminal arch of Kapβ2.
-<Structure load='4OO6' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />