5fd3: Difference between revisions
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==Structure of Lin54 tesmin domain bound to DNA== | |||
<StructureSection load='5fd3' size='340' side='right' caption='[[5fd3]], [[Resolution|resolution]] 2.42Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fd3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FD3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fd3 OCA], [http://pdbe.org/5fd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fd3 RCSB], [http://www.ebi.ac.uk/pdbsum/5fd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fd3 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/LIN54_HUMAN LIN54_HUMAN]] Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Felthousen, J G]] | |||
[[Category: Goetsch, P D]] | |||
[[Category: Lee, H]] | |||
[[Category: Litovchick, L]] | [[Category: Litovchick, L]] | ||
[[Category: | [[Category: Marceau, A H]] | ||
[[Category: | [[Category: Rubin, S M]] | ||
[[Category: Strome, S]] | [[Category: Strome, S]] | ||
[[Category: | [[Category: Tripathi, S M]] | ||
[[Category: Tesmin domain]] | |||
[[Category: Transcription factor]] | |||
[[Category: Transcription-dna complex]] | |||
Revision as of 04:14, 4 August 2016
Structure of Lin54 tesmin domain bound to DNA
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