5jyp: Difference between revisions
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==Allosteric inhibition of Kidney Isoform of Glutaminase== | |||
<StructureSection load='5jyp' size='340' side='right' caption='[[5jyp]], [[Resolution|resolution]] 2.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jyp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZBS:2-PHENYL-~{N}-[5-[(1~{S},3~{S})-3-[5-(2-PHENYLETHANOYLAMINO)-1,3,4-THIADIAZOL-2-YL]CYCLOHEXYL]-1,3,4-THIADIAZOL-2-YL]ETHANAMIDE'>ZBS</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jyo|5jyo]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutaminase Glutaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.2 3.5.1.2] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyp OCA], [http://pdbe.org/5jyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyp RCSB], [http://www.ebi.ac.uk/pdbsum/5jyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Glutaminase]] | |||
[[Category: Ramachandran, S]] | |||
[[Category: Sivaraman, J]] | |||
[[Category: Allosteric inhibition]] | |||
[[Category: Gac]] | |||
[[Category: Hydrolase]] | |||
[[Category: Kga]] | |||
[[Category: Warburg effect]] | |||
Revision as of 04:19, 4 August 2016
Allosteric inhibition of Kidney Isoform of Glutaminase
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