5kdl: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5kdl is ~~ON HOLD until Paper Publication~~

==Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS==

~~Authors~~: ~~Kaya~~, A.I., ~~Lokits~~, A.D.~~, Gilbert, J~~., ~~Iverson, T~~.M.~~, Meiler, J~~., ~~Hamm, H~~.E.

== Structural highlights ==

<table><tr><td colspan='2'>[[5kdl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDL OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KDL FirstGlance].

~~Description~~: ~~Crystal structure~~ of the ~~4 alanine insertion variant~~ of the ~~Gi alpha1 subunit bound~~ to ~~GTPgammaS~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

~~[[Category: Unreleased Structures]]~~

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5kdo|5kdo]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdl OCA], [http://pdbe.org/5kdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kdl RCSB], [http://www.ebi.ac.uk/pdbsum/5kdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdl ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Gilbert, J]]

[[Category: Lokits, A.D]]

[[Category: Hamm, H E]]

[[Category: Iverson, T M]]

[[Category: Kaya, A I]]

[[Category: Lokits, A D]]

[[Category: Meiler, J]]

[[Category: ~~Iverson, T.M~~]]

[[Category: Heterotrimeric g protein g protein coupled receptors g protein activation g protein structure gdp release]]

[[Category: ~~Hamm, H.E]]~~

[[Category: Signaling protein]]

~~[[Category: Kaya, A.I~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5kdl is ON HOLD  until Paper Publication
+==Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS==
+<StructureSection load='5kdl' size='340' side='right' caption='[[5kdl]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
-Authors: Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5kdl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KDL FirstGlance]. <br>
-Description: Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kdo|5kdo]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdl OCA], [http://pdbe.org/5kdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kdl RCSB], [http://www.ebi.ac.uk/pdbsum/5kdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdl ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Gilbert, J]]
-[[Category: Lokits, A.D]]
+[[Category: Hamm, H E]]
+[[Category: Iverson, T M]]
+[[Category: Kaya, A I]]
+[[Category: Lokits, A D]]
 [[Category: Meiler, J]]
-[[Category: Iverson, T.M]]
+[[Category: Heterotrimeric g protein g protein coupled receptors g protein activation g protein structure gdp release]]
-[[Category: Hamm, H.E]]
+[[Category: Signaling protein]]
-[[Category: Kaya, A.I]]