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==VBHT Fic protein from BARTONELLA SCHOENBUCHENSIS in complex with VBHA antitoxin==
==VBHT Fic protein from BARTONELLA SCHOENBUCHENSIS in complex with VBHA antitoxin==
<StructureSection load='3shg' size='340' side='right' caption='[[3shg]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3shg' size='340' side='right' caption='[[3shg]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3shg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_schoenbuchensis_r1 Bartonella schoenbuchensis r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHG FirstGlance]. <br>
<table><tr><td colspan='2'>[[3shg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Barsr Barsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jk8|2jk8]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jk8|2jk8]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B11C_100026 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=687861 Bartonella schoenbuchensis R1]), B11C_100027 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=687861 Bartonella schoenbuchensis R1])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B11C_100026 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=687861 BARSR]), B11C_100027 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=687861 BARSR])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3shg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3shg RCSB], [http://www.ebi.ac.uk/pdbsum/3shg PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3shg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shg OCA], [http://pdbe.org/3shg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3shg RCSB], [http://www.ebi.ac.uk/pdbsum/3shg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3shg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/E6Z0R3_9RHIZ E6Z0R3_9RHIZ]] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [[http://www.uniprot.org/uniprot/E6Z0R4_9RHIZ E6Z0R4_9RHIZ]] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.  
[[http://www.uniprot.org/uniprot/VBHT_BARSR VBHT_BARSR]] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [[http://www.uniprot.org/uniprot/VBHA_BARSR VBHA_BARSR]] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3shg" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bartonella schoenbuchensis r1]]
[[Category: Barsr]]
[[Category: Goepfert, A]]
[[Category: Goepfert, A]]
[[Category: Schirmer, T]]
[[Category: Schirmer, T]]
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