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==Crystal structure of EGFR kinase domain in complex with compound 4c==
==Crystal structure of EGFR kinase domain in complex with compound 4c==
<StructureSection load='4jrv' size='340' side='right' caption='[[4jrv]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4jrv' size='340' side='right' caption='[[4jrv]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jrv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JRV FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jrv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JRV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KJV:4-(DIMETHYLAMINO)-N-[3-(4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO}-6-PHENYLFURO[2,3-D]PYRIMIDIN-5-YL)PHENYL]BUTANAMIDE'>KJV</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KJV:4-(DIMETHYLAMINO)-N-[3-(4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO}-6-PHENYLFURO[2,3-D]PYRIMIDIN-5-YL)PHENYL]BUTANAMIDE'>KJV</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jq7|4jq7]], [[4jq8|4jq8]], [[4jr3|4jr3]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jq7|4jq7]], [[4jq8|4jq8]], [[4jr3|4jr3]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jrv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jrv RCSB], [http://www.ebi.ac.uk/pdbsum/4jrv PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jrv OCA], [http://pdbe.org/4jrv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jrv RCSB], [http://www.ebi.ac.uk/pdbsum/4jrv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jrv ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4jrv" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Peng, Y H]]
[[Category: Peng, Y H]]
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