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==HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 4c==
==HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 4c==
<StructureSection load='3gnw' size='340' side='right' caption='[[3gnw]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
<StructureSection load='3gnw' size='340' side='right' caption='[[3gnw]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3gnw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_isolate_hc-j4 Hepatitis c virus isolate hc-j4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GNW FirstGlance]. <br>
<table><tr><td colspan='2'>[[3gnw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GNW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XNC:(11S)-11-[4-(BENZYLOXY)-2-FLUOROPHENYL]-3,3-DIMETHYL-10-[(6-METHYLPYRIDIN-2-YL)CARBONYL]-2,3,4,5,10,11-HEXAHYDROTHIOPYRANO[3,2-B][1,5]BENZODIAZEPIN-6-OL+1,1-DIOXIDE'>XNC</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XNC:(11S)-11-[4-(BENZYLOXY)-2-FLUOROPHENYL]-3,3-DIMETHYL-10-[(6-METHYLPYRIDIN-2-YL)CARBONYL]-2,3,4,5,10,11-HEXAHYDROTHIOPYRANO[3,2-B][1,5]BENZODIAZEPIN-6-OL+1,1-DIOXIDE'>XNC</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cso|3cso]], [[3gnv|3gnv]], [[3gol|3gol]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cso|3cso]], [[3gnv|3gnv]], [[3gol|3gol]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=420174 Hepatitis C virus isolate HC-J4])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=420174 HCV])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gnw RCSB], [http://www.ebi.ac.uk/pdbsum/3gnw PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gnw OCA], [http://pdbe.org/3gnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gnw RCSB], [http://www.ebi.ac.uk/pdbsum/3gnw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gnw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3gnw" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hepatitis c virus isolate hc-j4]]
[[Category: Hcv]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Bondt, H De]]
[[Category: Bondt, H De]]
Retrieved from "https://proteopedia.org/3gnw"