2wrm: Difference between revisions

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==IDENTIFICATION OF NOVEL ALLOSTERIC INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE THUMB DOMAIN (SITE II) BY STRUCTURE-BASED DESIGN==

== Structural highlights ==

<table><tr><td colspan='2'>[[2wrm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Hepatitis_c_virus Hepatitis c virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRM OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRM FirstGlance].

<table><tr><td colspan='2'>[[2wrm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRM OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRM FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=QQ3:(3R)-3-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLIN-2-YL)HEXANOIC+ACID'>QQ3</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wrm RCSB], [http://www.ebi.ac.uk/pdbsum/2wrm PDBsum]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrm OCA], [http://pdbe.org/2wrm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wrm RCSB], [http://www.ebi.ac.uk/pdbsum/2wrm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrm ProSAT]</td></tr>

</table>

== Function ==

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__TOC__

</StructureSection>

~~[[Category: Hepatitis c virus]]~~

[[Category: RNA-directed RNA polymerase]]

[[Category: Marco, S Di]]

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 ==IDENTIFICATION OF NOVEL ALLOSTERIC INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE THUMB DOMAIN (SITE II) BY STRUCTURE-BASED DESIGN==
 <StructureSection load='2wrm' size='340' side='right' caption='[[2wrm]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wrm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wrm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRM FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QQ3:(3R)-3-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLIN-2-YL)HEXANOIC+ACID'>QQ3</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhu|1nhu]], [[2i1r|2i1r]], [[2wcx|2wcx]], [[1jxp|1jxp]], [[1gx6|1gx6]], [[2jc1|2jc1]], [[8ohm|8ohm]], [[1c2p|1c2p]], [[1a1q|1a1q]], [[1bt7|1bt7]], [[1cu1|1cu1]], [[1ns3|1ns3]], [[2jc0|2jc0]], [[2ax1|2ax1]], [[2who|2who]], [[1nhv|1nhv]], [[1csj|1csj]], [[1gx5|1gx5]], [[2brk|2brk]], [[2brl|2brl]], [[2awz|2awz]], [[2ax0|2ax0]], [[1quv|1quv]], [[1os5|1os5]]</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wrm RCSB], [http://www.ebi.ac.uk/pdbsum/2wrm PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrm OCA], [http://pdbe.org/2wrm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wrm RCSB], [http://www.ebi.ac.uk/pdbsum/2wrm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrm ProSAT]</span></td></tr>
 </table>
 == Function ==
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 __TOC__
 </StructureSection>
-[[Category: Hepatitis c virus]]
 [[Category: RNA-directed RNA polymerase]]
 [[Category: Marco, S Di]]