4ap7: Difference between revisions

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==Crystal structure of C-MET kinase domain in complex with 4-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl)phenol==
==Crystal structure of C-MET kinase domain in complex with 4-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl)phenol==
<StructureSection load='4ap7' size='340' side='right' caption='[[4ap7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4ap7' size='340' side='right' caption='[[4ap7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ap7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ap7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F47:4-[[6-(4-FLUOROPHENYL)-[1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZIN-3-YL]METHYL]PHENOL'>F47</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F47:4-[[6-(4-FLUOROPHENYL)-[1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZIN-3-YL]METHYL]PHENOL'>F47</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fyr|1fyr]], [[1r0p|1r0p]], [[1r1w|1r1w]], [[1shy|1shy]], [[1ssl|1ssl]], [[1ux3|1ux3]], [[2cew|2cew]], [[2g15|2g15]], [[2uzx|2uzx]], [[2uzy|2uzy]], [[2wd1|2wd1]], [[2wgj|2wgj]], [[2wkm|2wkm]], [[3zxz|3zxz]], [[3zze|3zze]], [[4aoi|4aoi]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fyr|1fyr]], [[1r0p|1r0p]], [[1r1w|1r1w]], [[1shy|1shy]], [[1ssl|1ssl]], [[1ux3|1ux3]], [[2cew|2cew]], [[2g15|2g15]], [[2uzx|2uzx]], [[2uzy|2uzy]], [[2wd1|2wd1]], [[2wgj|2wgj]], [[2wkm|2wkm]], [[3zxz|3zxz]], [[3zze|3zze]], [[4aoi|4aoi]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ap7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ap7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ap7 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ap7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap7 OCA], [http://pdbe.org/4ap7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ap7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ap7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ap7 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4ap7" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Mctigue, M]]
[[Category: Mctigue, M]]
[[Category: Wickersham, J]]
[[Category: Wickersham, J]]
[[Category: Transferase]]
[[Category: Transferase]]
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