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==Crystal structure of a novel dimeric form of HCV NS5A domain I protein==
==Crystal structure of a novel dimeric form of HCV NS5A domain I protein==
<StructureSection load='3fqq' size='340' side='right' caption='[[3fqq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3fqq' size='340' side='right' caption='[[3fqq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3fqq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FQQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3fqq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FQQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0BD:3-METHYL-1-(2-METHYLPROPYL)BUTYL+4-O-BETA-L-GULOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>0BD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0BD:3-METHYL-1-(2-METHYLPROPYL)BUTYL+4-O-BETA-L-GULOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>0BD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zh1|1zh1]], [[2fqm|2fqm]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zh1|1zh1]], [[2fqm|2fqm]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nonstructural protein NS5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nonstructural protein NS5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333284 HCV])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fqq RCSB], [http://www.ebi.ac.uk/pdbsum/3fqq PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqq OCA], [http://pdbe.org/3fqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fqq RCSB], [http://www.ebi.ac.uk/pdbsum/3fqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fqq ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3fqq" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Viruses]]
[[Category: Hcv]]
[[Category: Love, R A]]
[[Category: Love, R A]]
[[Category: Domain i]]
[[Category: Domain i]]
[[Category: Hcv]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
[[Category: Ns5a]]
[[Category: Ns5a]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Rna-binding]]
[[Category: Rna-binding]]
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