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==Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors==
==Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors==
<StructureSection load='2ym3' size='340' side='right' caption='[[2ym3]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='2ym3' size='340' side='right' caption='[[2ym3]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ym3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YM3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ym3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YM3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=YM3:ETHYL+4-(2-(AMINOMETHYL)MORPHOLINO)-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE'>YM3</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=YM3:ETHYL+4-(2-(AMINOMETHYL)MORPHOLINO)-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE'>YM3</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xf0|2xf0]], [[2brb|2brb]], [[2x8d|2x8d]], [[2wmr|2wmr]], [[2cgv|2cgv]], [[2brn|2brn]], [[2wmx|2wmx]], [[2yer|2yer]], [[2ayp|2ayp]], [[2cgu|2cgu]], [[1nvs|1nvs]], [[2brm|2brm]], [[2ydj|2ydj]], [[1nvq|1nvq]], [[2ydi|2ydi]], [[2wmt|2wmt]], [[2cgx|2cgx]], [[2c3j|2c3j]], [[2bro|2bro]], [[2wmw|2wmw]], [[2wmu|2wmu]], [[2brh|2brh]], [[2x8e|2x8e]], [[2c3k|2c3k]], [[1nvr|1nvr]], [[2wmq|2wmq]], [[1zlt|1zlt]], [[2cgw|2cgw]], [[2yex|2yex]], [[2xez|2xez]], [[1zys|1zys]], [[1ia8|1ia8]], [[2br1|2br1]], [[2brg|2brg]], [[2ydk|2ydk]], [[2wmv|2wmv]], [[2wms|2wms]], [[2x8i|2x8i]], [[2c3l|2c3l]], [[2xey|2xey]], [[2ym8|2ym8]], [[2ym5|2ym5]], [[2ym4|2ym4]], [[2ym7|2ym7]], [[2ym6|2ym6]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xf0|2xf0]], [[2brb|2brb]], [[2x8d|2x8d]], [[2wmr|2wmr]], [[2cgv|2cgv]], [[2brn|2brn]], [[2wmx|2wmx]], [[2yer|2yer]], [[2ayp|2ayp]], [[2cgu|2cgu]], [[1nvs|1nvs]], [[2brm|2brm]], [[2ydj|2ydj]], [[1nvq|1nvq]], [[2ydi|2ydi]], [[2wmt|2wmt]], [[2cgx|2cgx]], [[2c3j|2c3j]], [[2bro|2bro]], [[2wmw|2wmw]], [[2wmu|2wmu]], [[2brh|2brh]], [[2x8e|2x8e]], [[2c3k|2c3k]], [[1nvr|1nvr]], [[2wmq|2wmq]], [[1zlt|1zlt]], [[2cgw|2cgw]], [[2yex|2yex]], [[2xez|2xez]], [[1zys|1zys]], [[1ia8|1ia8]], [[2br1|2br1]], [[2brg|2brg]], [[2ydk|2ydk]], [[2wmv|2wmv]], [[2wms|2wms]], [[2x8i|2x8i]], [[2c3l|2c3l]], [[2xey|2xey]], [[2ym8|2ym8]], [[2ym5|2ym5]], [[2ym4|2ym4]], [[2ym7|2ym7]], [[2ym6|2ym6]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ym3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ym3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ym3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ym3 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ym3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ym3 OCA], [http://pdbe.org/2ym3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ym3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ym3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ym3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2ym3" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Addison, G]]
[[Category: Addison, G]]
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