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==Crystal Structure of the CDK2 in complex with thiazolylpyrimidine inhibitor==
==Crystal Structure of the CDK2 in complex with thiazolylpyrimidine inhibitor==
<StructureSection load='3sw7' size='340' side='right' caption='[[3sw7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3sw7' size='340' side='right' caption='[[3sw7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3sw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SW7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3sw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SW7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19K:N~4~-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-N~1~,N~1~-DIMETHYL-2-NITROBENZENE-1,4-DIAMINE'>19K</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19K:N~4~-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-N~1~,N~1~-DIMETHYL-2-NITROBENZENE-1,4-DIAMINE'>19K</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rcs|3rcs]], [[3rct|3rct]], [[3rcu|3rcu]], [[3rdf|3rdf]], [[3rcv|3rcv]], [[3sm6|3sm6]], [[3sm7|3sm7]], [[3smw|3smw]], [[3smx|3smx]], [[3smy|3smy]], [[3snj|3snj]], [[3sqt|3sqt]], [[3squ|3squ]], [[3srl|3srl]], [[3srm|3srm]], [[3sro|3sro]], [[3sts|3sts]], [[3su7|3su7]], [[3sw4|3sw4]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rcs|3rcs]], [[3rct|3rct]], [[3rcu|3rcu]], [[3rdf|3rdf]], [[3rcv|3rcv]], [[3sm6|3sm6]], [[3sm7|3sm7]], [[3smw|3smw]], [[3smx|3smx]], [[3smy|3smy]], [[3snj|3snj]], [[3sqt|3sqt]], [[3squ|3squ]], [[3srl|3srl]], [[3srm|3srm]], [[3sro|3sro]], [[3sts|3sts]], [[3su7|3su7]], [[3sw4|3sw4]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sw7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sw7 RCSB], [http://www.ebi.ac.uk/pdbsum/3sw7 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sw7 OCA], [http://pdbe.org/3sw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sw7 RCSB], [http://www.ebi.ac.uk/pdbsum/3sw7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sw7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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==See Also==
==See Also==
*[[Cell division protein kinase 2|Cell division protein kinase 2]]
*[[Cyclin-dependent kinase|Cyclin-dependent kinase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Kang, Y N]]
[[Category: Kang, Y N]]
[[Category: Stuckey, J A]]
[[Category: Stuckey, J A]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/3sw7"