Rhomboid protease: Difference between revisions
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<StructureSection load='2xow' size='350' side='right' caption='Structure of rhomboid protease complex with inhibitor isocoumarin and nonyglucoside detergent molecules (PDB entry [[2xow]])' scene=''> | <StructureSection load='2xow' size='350' side='right' caption='Structure of rhomboid protease complex with inhibitor isocoumarin and nonyglucoside detergent molecules (PDB entry [[2xow]])' scene=''> | ||
== Function == | == Function == | ||
'''Rhomboid protease''' is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. | '''Rhomboid protease''' (GlpG) is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. | ||
== Structural highlights == | == Structural highlights == | ||
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**[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR /> | **[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR /> | ||
**[[2xtu]], [[3b44]], [[2xtv]] – EcGlpG core region (mutant) <BR /> | **[[2xtu]], [[3b44]], [[2xtv]], [[5f5d]] – EcGlpG core region (mutant) <BR /> | ||
**[[4hdd]] – EcGlpG N terminal <BR /> | **[[4hdd]] – EcGlpG N terminal <BR /> | ||
**[[2lep]], [[2mja]] – EcGlpG N terminal - NMR <BR /> | **[[2lep]], [[2mja]] – EcGlpG N terminal - NMR <BR /> | ||
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**[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR /> | **[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR /> | ||
**[[3zmh]], [[3zmi]], [[3zmj]], [[3zot]] – EcGlpG core region + β-lactam inhibitor <BR /> | **[[3zmh]], [[3zmi]], [[3zmj]], [[3zot]] – EcGlpG core region + β-lactam inhibitor <BR /> | ||
**[[5f5j]], [[5f5k]] – EcGlpG core region (mutant) + aldehyde inhibitor <BR /> | |||
**[[4qnz]] – EcGlpG core region (mutant) + peptide inhibitor <BR /> | **[[4qnz]] – EcGlpG core region (mutant) + peptide inhibitor <BR /> | ||
**[[4qo0]], [[4qo2]] – EcGlpG core region + peptide inhibitor <BR /> | **[[4qo0]], [[4qo2]], [[5f5g]], [[5f5b]] – EcGlpG core region + peptide inhibitor <BR /> | ||
}} | }} | ||
